Pediatric Population Pharmacokinetic Modeling and Exposure–Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data-Reference-Cited by-同舟云学术

Pediatric Population Pharmacokinetic Modeling and Exposure–Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data

Published:2023-01-29 Issue:5 Volume:63 Page:593-603
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharma

Author:

Okour Malek¹^ORCID,Thapar Mita M.²,Farrell Colm²,Lukas Mary Ann³,Beghetti Maurice⁴,Beerahee Misba⁵

Affiliation:

1. Clinical Pharmacology Modeling and Simulation GSK Collegeville Pennsylvania USA

2. ICON Clinical Research Reading Berkshire UK

3. Metabolic Pathways and Cardiovascular Therapeutic Area GSK Collegeville Pennsylvania USA

4. Pediatric Cardiology Unit University Children's Hospital Pulmonary Hypertension Program University of Geneva and Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pédiatrique (CURCCCP) University of Geneva and Lausanne Geneva Switzerland

5. Clinical Pharmacology Modeling and Simulation GSK Stevenage Hertfordshire UK

Funder

GlaxoSmithKline

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.2199

Reference26 articles.

1. Treatment of Pulmonary Arterial Hypertension

2. Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management

3. FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion

4. Safety Experience With Bosentan in 146 Children 2–11 Years Old With Pulmonary Arterial Hypertension: Results from the European Postmarketing Surveillance Program

5. A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of Oral Sildenafil Citrate in Treatment-Naive Children With Pulmonary Arterial Hypertension

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1. Long-term safety and tolerability of ambrisentan treatment for pediatric patients with pulmonary arterial hypertension: An open-label extension study;European Journal of Pediatrics;2024-02-16