Spinal cord injury: Olfactory ensheathing cell‐based therapeutic strategies

Author:

Chen Xinli1,Liu Yibin1,Stavrinou Pantelis23,Stavrinou Lampis4,Hu Weipeng5,Goldbrunner Roland2,Zheng Feng5,He Hefan1ORCID

Affiliation:

1. Department of Anesthesiology The Second Affiliated Hospital of Fujian Medical University Quanzhou China

2. Department of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital University of Cologne Cologne Germany

3. Neurosurgery Metropolitan Hospital Athens Greece

4. 2nd Department of Neurosurgery “Attikon” University Hospital, National and Kapodistrian University, Athens Medical School Athens Greece

5. Department of Neurosurgery The Second Affiliated Hospital of Fujian Medical University Quanzhou China

Abstract

AbstractSpinal cord injury (SCI) is a highly disabling neurological disorder that is difficult to treat due to its complex pathophysiology and nerve regeneration difficulties. Hence, effective SCI treatments are necessary. Olfactory ensheathing cells (OECs), glial cells derived from the olfactory bulb or mucosa, are ideal candidates for SCI treatment because of their neuroprotective and regenerative properties, ample supply, and convenience. In vitro, animal model, and human trial studies have reported discoveries on OEC transplantation; however, shortcomings have also been demonstrated. Recent studies have optimized various OEC transplantation strategies, including drug integration, biomaterials, and gene editing. This review aims to introduce OECs mechanisms in repairing SCI, summarize the research progress of OEC transplantation‐optimized strategies, and provide novel research ideas for SCI treatment.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

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