MUC5AChypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer

Author:

Renaud Florence123,Vincent Audrey134,Mariette Christophe135,Crépin Michel6,Stechly Laurence16,Truant Stéphanie135,Copin Marie-Christine123,Porchet Nicole136,Leteurtre Emmanuelle123,Van Seuningen Isabelle134,Buisine Marie-Pierre136

Affiliation:

1. Inserm, UMR837, Team 5 “Mucins, Epithelial Differentiation and Carcinogenesis,” Jean-Pierre Aubert Research Center; Lille France

2. Pathology Institute, Biology Pathology Center, Lille University Hospital; Lille France

3. North of France University; Lille France

4. Lille University Hospital; Lille France

5. Digestive Surgery Department; Claude Huriez Hospital, Lille University Hospital; Lille France

6. Department of Molecular Oncology and Genetics; Biochemistry and Molecular Biology Institute, Biology Pathology Center, Lille University Hospital; Lille France

Funder

European Fund for Economic and Regional Development (FEDER)

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference43 articles.

1. International trends in colorectal cancer incidence rates;Center;Cancer Epidemiol Biomarkers Prev,2009

2. Genomic and epigenetic instability in colorectal cancer pathogenesis;Grady;Gastroenterology,2008

3. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression;Deng;Cancer Res,1999

4. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications;Lynch;Clin Genet,2009

5. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features;Jass;Histopathology,2007

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