ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision-Reference-Cited by-同舟云学术

ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision

Published:2018-05-15 Issue:5 Volume:104 Page:781-784
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Zamek-Gliszczynski Maciej J.¹,Chu Xiaoyan²,Cook Jack A.³,Custodio Joseph M.⁴,Galetin Aleksandra⁵,Giacomini Kathleen M.⁶,Lee Caroline A.⁷,Paine Mary F.⁸,Ray Adrian S.⁹,Ware Joseph A.¹⁰,Wittwer Matthias B.¹¹,Zhang Lei¹²,

Affiliation:

1. Quantitative Drug Disposition; GlaxoSmithKline plc; King of Prussia Pennsylvania USA

2. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism; Merck & Co., Inc; Kenilworth New Jersey USA

3. Clinical Pharmacology, Global Product Development; Pfizer Inc.; Groton Connecticut USA

4. Clinical Pharmacology; Gilead Sciences Inc.; Foster City California USA

5. Centre for Applied Pharmacokinetic Research, School of Health Sciences; University of Manchester; Manchester UK

6. Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine; University of California; San Francisco California USA

7. Drug Metabolism and Clinical Pharmacology; DMPK Solutions; San Diego California USA

8. Department of Pharmaceutical Sciences, College of Pharmacy; Washington State University; Spokane Washington USA

9. Clinical Research; Gilead Sciences, Inc.; Foster City California USA

10. Clinical Pharmacology; Genentech; South San Francisco California USA

11. Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel; F. Hoffmann-La Roche Ltd; Basel Switzerland

12. Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration; Silver Spring; Maryland USA

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.1082/fullpdf

Reference10 articles.

1. Metformin pathways: pharmacokinetics and pharmacodynamics;Gong;Pharmacogenet. Genomics,2012

2. Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers;Cho;Br. J. Clin. Pharmacol,2014

3. Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants;Cho;Clin. Pharmacol. Ther.,2011