Prediction of complications of pre‐eclampsia using the fullPIERS high risk predictive model

Abstract

AbstractObjectiveTo determine the predicted probability percentage of complications in women with pre‐eclampsia using the Pre‐eclampsia Integrated Estimate of Risk (fullPIERS) model within the first 24 h after admission and assess the model's predictive value for complications of pre‐eclampsia.MethodsThis was a prospective cohort study in which the fullPIERS model was applied to 256 pregnant women with pre‐eclampsia within the first 24 h after admission. These women were then followed for 48 h to 7 days for maternal and fetal complications. Reciever operating characteristics (ROC) curves were generated to assess the performance of the fullPIERS model for adverse outcomes of pre‐eclampsia.ResultsOf the 256 women enrolled in the study, 101 women (39.5%) developed maternal complications, 120 women (46.9%) developed fetal complications, and 159 women (62.1%) developed both. With an area under the ROC curve of 0.843 (95% confidence interval 0.789–0.897), the fullPIERS model had good discriminating ability to predict complications at any time point between 48 h and 7 days after admission. The sensitivity and specificity of the model at a ≥5.9% cut‐off value for predicting adverse maternal outcomes were 60% and 97%, respectively; they were 44% and 96%, respectively, for predicting combined fetomaternal complications with a cut‐off value of 4.9%.ConclusionsThe fullPIERS model performs reasonably well in predicting adverse maternal and fetal outcomes in women with pre‐eclampsia.