Sex‐dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial

Author:

Innominato Pasquale F.123,Ballesta Annabelle23,Huang Qi24,Focan Christian5,Chollet Philippe6,Karaboué Abdoulaye7,Giacchetti Sylvie38,Bouchahda Mohamed3910,Adam René311,Garufi Carlo12,Lévi Francis A.2310ORCID

Affiliation:

1. North Wales Cancer CentreBetsi Cadwaladr University Health Board Bangor United Kingdom

2. Division of Biomedical Sciences Cancer Chronotherapy TeamCancer Research CentreWarwick Medical School Coventry United Kingdom

3. UMRS 935, "Cancer Chronotherapy and Postoperative Liver Functions" French National Institute for Health and Medical Research (INSERM) and Paris‐Sud University Villejuif France

4. Department of Statistics University of Warwick Coventry United Kingdom

5. Department of Oncology Clinique Saint‐JosephCHC‐Liège Hospital Group Liège Belgium

6. Clinical and Translational Research Division Jean Perrin Comprehensive Cancer Centre Clermont‐Ferrand France

7. Medical Oncology Unit GHI Le Raincy‐Montfermeil Montfermeil France

8. Department of Oncology Saint Louis HospitalPublic Hospitals of Paris (AP‐HP) Paris France

9. Mousseau Clinics Evry France

10. Chronotherapy Unit Department of Medical Oncology Paul Brousse HospitalPublic Hospitals of Paris (AP‐HP) Villejuif France

11. Hepatobiliary Centre Paul Brousse HospitalAP‐HP Villejuif France

12. Division of Medical Oncology San Camillo Forlanini Hospital Roma Italy

Funder

Medical Research Council

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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