A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on <scp>ADHD</scp>-Reference-Cited by-同舟云学术

A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD

Published:2024-04-16 Issue:2 Volume:44 Page:300-307
ISSN:2574-173X
Container-title:Neuropsychopharmacology Reports
language:en
Short-container-title:Neuropsychopharm Rep

Author:

Allahyari Pooneh¹,Abbas Torki Saheb²,Aminnezhad Kavkani Bahareh³,Mahmoudi Zahra³,Mousavi Hoseini Mohadeseh Sadat⁴,Moradi Mahdi⁵,Alami Farkhondeh⁶,Keshavarz Mohammadian Mohammad³,Bahoo Sele Bani Samira⁷,Abbasi Mobarakeh Khadijeh⁸,Shafaei Hanieh⁹,Khoshdooz Sara⁹,Hajipour Azadeh¹⁰,Doaei Saeid¹¹^ORCID,Gholamalizadeh Maryam¹²

Affiliation:

1. Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences Islamic Azad University, Central Tehran Branch Tehran Iran

2. Department of Nutrition, Faculty of Nutrition Sciences Shiraz University of Medical Sciences Shiraz Iran

3. Department of Nutrition, Science and Research Branch Islamic Azad University Tehran Iran

4. Department of Food Science and Technology, Science and Research Branch Islamic Azad University Tehran Iran

5. Department of Clinical Psychology Payame Noor University Tehran Iran

6. Student Research Committee, Department of Nutrition, Faculty of Medicine Urmia University of Medical Sciences Urmia Iran

7. Islamic Azad University, Roudehen Branch Tehran Iran

8. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences Isfahan Iran

9. Shahid Beheshti College of Midwifery Gilan University of Medical Sciences Rasht Iran

10. School of Health Qazvin University of Medical Sciences Qazvin Iran

11. Reproductive Health Research Center, Al‐Zahra Hospital Guilan University of Medical Sciences Rasht Iran

12. Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Abstract

AbstractBackgroundChildren with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted.MethodsThe present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria.ResultsResearch on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health‐related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels.ConclusionThe use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD.

Funder

Shahid Beheshti University

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/npr2.12437

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