The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio
Author:
Affiliation:
1. Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine; University of California San Francisco; San Francisco California USA
Funder
NIH
China Scholarship Council
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Reference15 articles.
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2. A physiologic approach to hepatic drug clearance;Wilkinson;Clin. Pharmacol. Ther.,1975
3. Winkler , K. Keiding , S. Tystruup , N In The Liver: Quantitative Aspects of Structure and Functions 144 155
4. A dispersion model of hepatic elimination. 1. Formulation of the model and bolus considerations;Roberts;J. Pharmacokinet. Biopharm.,1986
5. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well stirred” model over the “Parallel Tube” model using lidocaine in the perfused rat liver in situ preparation;Pang;J. Pharmacokinet. Biopharm.,1977
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