The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio-Reference-Cited by-同舟云学术

The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio

Published:2017-09-06 Issue:3 Volume:103 Page:521-525
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Benet LZ¹,Liu S¹,Wolfe AR¹

Affiliation:

1. Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine; University of California San Francisco; San Francisco California USA

Funder

NIH

China Scholarship Council

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

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3. Winkler , K. Keiding , S. Tystruup , N In The Liver: Quantitative Aspects of Structure and Functions 144 155

4. A dispersion model of hepatic elimination. 1. Formulation of the model and bolus considerations;Roberts;J. Pharmacokinet. Biopharm.,1986

5. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well stirred” model over the “Parallel Tube” model using lidocaine in the perfused rat liver in situ preparation;Pang;J. Pharmacokinet. Biopharm.,1977

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