The aspartimide problem persists: Fluorenylmethyloxycarbonyl‐solid‐phase peptide synthesis (Fmoc‐SPPS) chain termination due to formation of N‐terminal piperazine‐2,5‐diones-Reference-Cited by-同舟云学术

The aspartimide problem persists: Fluorenylmethyloxycarbonyl‐solid‐phase peptide synthesis (Fmoc‐SPPS) chain termination due to formation of N‐terminal piperazine‐2,5‐diones

Published:2019-07 Issue:7 Volume:25 Page:
ISSN:1075-2617
Container-title:Journal of Peptide Science
language:en
Short-container-title:J Pep Sci

Author:

Samson Daniel¹,Rentsch Daniel²,Minuth Marco¹,Meier Thomas¹,Loidl Günther¹

Affiliation:

1. Bachem AG Hauptstrasse 144 CH‐4416 Bubendorf Switzerland

2. Swiss Federal Laboratories for Materials Science and Technology (EMPA)Laboratory for Functional Polymers Überlandstrasse 129 CH‐8600 Dübendorf Switzerland

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psc.3193

Reference27 articles.

1. Aspartimide formation in peptide chemistry: occurrence, prevention strategies and the role of N-hydroxylamines

2. The aspartimide problem in Fmoc-based SPPS. Part III

3. The aspartimide problem in Fmoc-based SPPS. Part II

4. The aspartimide problem in Fmoc-based SPPS. Part I

5. SIDE REACTIONS IN PEPTIDE SYNTHESIS

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