Tissue‐specific early and late activated lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps-Reference-Cited by-同舟云学术

Tissue‐specific early and late activated lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps

Published:2024-01-24 Issue: Volume: Page:
ISSN:2042-6976
Container-title:International Forum of Allergy & Rhinology
language:en
Short-container-title:Int Forum Allergy Rhinol

Author:

López‐Enríquez Soledad¹²^ORCID,Porras‐González Cristina¹²,Moreno‐Luna Ramón²³^ORCID,Palomares Francisca¹²,Muñoz‐Bravo José Luis⁴,Alba Gonzalo¹,Santa‐María Consuelo⁵,Maza‐Solano Juan²³,Martín‐Jiménez Daniel Iván²,Pérez‐Pérez Antonio¹,Moreno‐Luna Rafael⁶,Sánchez‐Margalet Víctor¹²,Sánchez‐Gómez Serafín²³

Affiliation:

1. Department of Medical Biochemistry Molecular Biology, and Immunology School of Medicine Virgen Macarena University Hospital Universidad de Sevilla Seville Spain

2. Institute of Biomedicine of Seville (IBiS)/Virgen del Rocío University Hospital/Virgen Macarena University Hospital/University of Seville/CSIC Seville Spain

3. Rhinology Unit, Department of Otolaryngology, Head and Neck Surgery Virgen Macarena University Hospital/FISEVI Seville Spain

4. Clinical Analysis Service General University Hospital of Elche, Foundation for the Promotion of Health and Biomedical Research in the Valencia Region (FISABIO) Elche Spain

5. Department of Biochemistry and Molecular Biology School of Pharmacy Universidad de Sevilla Seville Spain

6. Cooperative Research Networks aimed at Health Results Cerebral vascular diseases, RICORS‐ICTUS, SESCAM Toledo Spain

Abstract

Key points

T‐cell activation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is enriched by late cytotoxic T cells.

The proportion of early and intermediate activated cytotoxic T cells decreases in nasal polyps of patients with CRSwNP.

Our results identify late activated cytotoxic T cells as potential biomarkers or therapeutic targets for patients with CRSwNP.

Publisher

Wiley

Subject

Otorhinolaryngology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alr.23327

Reference10 articles.

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3. Chronic rhinosinusitis: phenotypes and endotypes

4. Tissue-specific Activated Regulatory Lymphocytes Immunophenotype in Chronic Rhinosinusitis with Nasal Polyps

5. Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function