Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence

Author:

Fujisawa Takeshi123ORCID,Motegi Atsushi13ORCID,Hirata Hidenari13ORCID,Zenda Sadamoto13,Hojo Hidehiro13,Nakamura Masaki13,Oyoshi Hidekazu1,Tomizawa Kento1ORCID,Zhou Yuzheng1,Fukushi Keiko1,Kageyama Shun‐Ichiro13,Enokida Tomohiro4,Okano Susumu4,Tahara Makoto4,Shinozaki Takeshi5,Hayashi Ryuichi5,Matsuura Kazuto5,Akimoto Tetsuo13

Affiliation:

1. Department of Radiation Oncology National Cancer Center Hospital East Kashiwa Japan

2. Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine Tokyo Japan

3. Division of Radiation Oncology and Particle Therapy Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Kashiwa Japan

4. Department of Head and Neck Medical Oncology National Cancer Center Hospital East Kashiwa Japan

5. Department of Head and Neck Surgery National Cancer Center Hospital East Kashiwa Japan

Abstract

AbstractBackgroundsWe aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer.MethodsWe retrospectively evaluated overall survival (OS), recurrence‐free survival (RFS), recurrence patterns, and adverse events of 51 patients with high‐risk features receiving PORT after salvage neck dissection between 2009 and 2019.ResultsAfter a median follow‐up of 7.4 years from PORT initiation, the 7‐year OS and RFS rates were 66.3% (95% CI: 54.0–81.3) and 54.6% (95% CI: 42.1–70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT‐related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed.ConclusionsPORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Otorhinolaryngology

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