Sensitive LC-MS/MS-ESI method for simultaneous determination of nifedipine and atenolol in human plasma and its application to a human pharmacokinetic study

Author:

Kallem Raja Reddy1,Inamadugu Jaswanth Kumar2,Ramesh Mullangi3,Seshagirirao J. V. L. N.1

Affiliation:

1. College of Pharmaceutical Sciences; Andhra University; Visakhapatnam-530 003 A.P. India

2. Wellquest Clinical Research Laboratories; Ramanthapur Hyderabad-500 013 India

3. Jubilant Biosys, 2 Stage; Industrial Suburb; Yeshwanthpur Bangalore-560 022 India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference17 articles.

1. Atenolol plus nifedipine for mild to moderate systemic hypertension after fixed doses of either agent alone;Daniels;The American Journal of Cardiology,1986

2. Royal Society of Medicine International Congress and Symposium, Series No. 22;Dollery,1980

3. Treatment of angina pectoris with nifedipine and atenolol: efficacy and effort of cardiac function;Findlay;British Heart Journal,1986

4. A study of the pharmacokinetics and pharmacodynamics of nifedipine in combination with atenolol;Fitzsimons;Biopharmaceutics & Drug Disposition,1991

5. LC-MS/MS method for the determination of several drugs used in combined cardiovascular therapy in human plasma;Gonzalez;Journal of Chromatography B,2010

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