Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges

Author:

Libes Jaime1ORCID,Hol Janna2,Neto Joaquim Caetano de Aguirre3,Vallance Kelly L.4,Tinteren Harm van2,Benedetti Daniel J.5,Villar Gema Lucia Ramirez6,Duncan Catriona7,Ehrlich Peter F.8

Affiliation:

1. Department of Pediatrics University of Illinois College of Medicine Peoria Illinois USA

2. Princess Máxima Center for Pediatric Oncology Utrecht Netherlands

3. Department of Oncology Hospital Santa Casa de Belo Horizonte Belo Horizonte Brazil

4. Hematology and Oncology Cook Children's Medical Center Fort Worth Texas USA

5. Department of Pediatrics Division of Hematology/Oncology Vanderbilt University Medical Center Nashville Tennessee USA

6. Hospital Universitario Virgen del Rocio Pediatric Oncology Unit University of Seville Seville Spain

7. Great Ormond Street Hospital for Children (GOSH) NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre London UK

8. Department of Pediatric Surgery C.S. Mott Children's Hospital University of Michigan School of Public Health Ann Arbor Michigan USA

Abstract

AbstractPediatric renal tumors account for 3%–11% of childhood cancers, the most common of which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer prevention and control by describing the distribution of cancer and discovering risk factors for cancer. Large pediatric research consortium trials have led to a clearer understanding of pediatric renal tumors, identification of risk factors, and development of more risk‐adapted therapies. These therapies have improved event‐free and overall survival for children. However, several challenges remain and not all children have benefited from the improved outcomes. In this article, we review the global epidemiology of pediatric renal tumors, including key consortium and global studies. We identify current knowledge gaps and challenges facing both high and low middle‐incomes countries.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

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4. Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil

5. International variations in the incidence of childhood renal tumours

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