Engineering the oleaginous yeast <i>Yarrowia lipolytica</i> to produce nutraceuticals: From metabolic design to industrial applications-Reference-Cited by-同舟云学术

Engineering the oleaginous yeast Yarrowia lipolytica to produce nutraceuticals: From metabolic design to industrial applications

Published:2023-09 Issue:3 Volume:2 Page:187-199
ISSN:2770-2081
Container-title:Food Bioengineering
language:en
Short-container-title:Food Bioengineering

Author:

Gu Yang¹²^ORCID,Lu Xueyao²,Liu Tongkang²,Song Yanjin²,Sang Ellie²,Ding Shuran²,Liu Long¹^ORCID,Xue Feng²,Xu Peng³⁴

Affiliation:

1. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education Jiangnan University Wuxi China

2. School of Food Science and Pharmaceutical Engineering Nanjing Normal University Nanjing China

3. Department of Chemical Engineering Guangdong Technion‐Israel Institute of Technology (GTIIT) Shantou Guangdong China

4. The Wolfson Department of Chemical Engineering Technion‐Israel Institute of Technology Haifa Israel

Abstract

AbstractThe oleaginous yeast, Yarrowia lipolytica, has garnered much attention and is gaining recognition as a potential industrial platform for nutraceutical production. The superior properties of Y. lipolytica include its transparent inherited background, broad substrate spectrum, and superior environmental tolerance. Specifically, advances in genetic tools and engineering strategies have further widened its applications in metabolic engineering and biomanufacturing. In this review, we summarized developments in synthetic biology and engineering strategies for constructing Y. lipolytica to produce nutraceuticals. We also proposed perspectives on the limitations and challenges in developing microbial Y. lipolytica factories.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/fbe2.12062

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