Bioactive Hydrogels with Pro‐coagulation Effect for Hemostasis†

Abstract

Comprehensive SummaryHemostatic hydrogels are widely applied for wound management of damaged tissues, traumatic wounds, and surgical incisions. Some hydrogels composed of bioactive components, including fibrin and thrombin, showed great promise in the clinic due to their good pro‐coagulation effect. With the expanding knowledge of cascade reaction of blood coagulation and emerging bioactive substances, massive bioactive hydrogels consisting of peptides, hemocoagulase, polyphosphate (polyP), etc., have been developed as effective hemostatic materials. Based on the coagulation process and mechanism, we summarize the role of reported bioactive hydrogels in hemostasis in this review. We conclude the key points in the coagulation process, including activation of coagulation factors, fibrinogen polymerization, etc., then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these points. Finally, we conclude the progress and propose a perspective of bioactive hydrogels with a pro‐coagulation effect for hemostasis.