Affiliation:
1. Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay 999077 Hong Kong SAR China
2. WPI Institute for Chemical Reaction Design and Discovery (WPI‐ICReDD) Hokkaido University Sapporo 001‐0021 Japan
Abstract
Comprehensive SummaryThe first total synthesis of neopetromin, featuring the highly strained Tyr C‐6‐to‐Trp N‐1’ linkage, is hereby reported. This modular synthetic strategy, employing C—H arylation and Larock macrocyclization, offers a novel approach to the synthesis of various RiPPs natural product families.