Affiliation:
1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China
Abstract
Comprehensive SummaryA new electrophilic monofluoromethylthiolating reagent N‐fluoromethylthiophthalimide PhthSCH2F 1 was developed. Reagent 1 could be readily synthesized from easily available starting materials benzyl mercaptan and CH2FCl in three steps. N‐Fluoromethylthiophthalimide 1 is a powerful electrophilic monofluoromethylthiolating reagent that allows the monofluoromethylthiolation of a wide range of nucleophiles including alkynes, aryl/vinyl boronic acids, electron‐rich heteroarenes, β‐ketoesters and oxindoles, as well as thiols under mild conditions.
Funder
National Basic Research Program of China
Cited by
2 articles.
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