Affiliation:
1. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science, Northwest University Xi'an Shaanxi 710127 China
Abstract
Comprehensive SummaryA general and efficient strategy for the synthesis of γ‐lactams has been reported. The hydroxylamines form Lossen rearrangement products of electron‐deficient group migration with base and then undergo [3+2] cycloaddition reaction with vinyl cyclopropane, which could be performed with broad substrate scope, excellent functional group tolerance and high efficiency to produce the desired products. It also allowed further modification to other derivatives of these γ‐lactams.
Funder
National Natural Science Foundation of China