Affiliation:
1. Pingyuan Laboratory Xinxiang Henan 453007 China
2. School of Food Science and Pharmaceutical Engineering Nanjing Normal University Nanjing Jiangsu 210023 China
3. China Frontiers Science Center for Transformative Molecules (FSCTM), Center for Chemical Glycobiology, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Shanghai 200240 China
Abstract
Comprehensive SummaryA highly stereoselective nickel‐catalyzed cross‐electrophile coupling of readily accessible, novel, stable oxygen‐based glycosyl radical precursors, specifically 1,2‐glycosyl orthoesters, is developed. This approach offers an effective pathway to synthesize diverse C‐vinyl glycosides, characterized by good yields, excellent stereoselectivity, mild reaction conditions, a broad substrate scope, and versatile transformations of the resulting products.
Funder
Natural Science Foundation of Shanghai Municipality
Fundamental Research Funds for the Central Universities
National Science Foundation of Sri Lanka
National Key Research and Development Program of China