Affiliation:
1. Hainan Pharmaceutical Research and Development Science Park, Hainan Academy of Medical Sciences Hainan Medical University No. 3 Xueyuan Road Haikou Hainan 571199 China
2. Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography Ministry of Natural Resources 184 Daxue Road Xiamen Fujian 361005 China
3. School of Pharmaceutical Sciences Xiamen University South Xiangan Road Xiamen Fujian 361102 China
Abstract
Comprehensive SummaryA chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi MCCC 3A00580 resulted in the discovery of four new meroterpenoids (1—4) and one related known co‐metabolite (5). These meroterpenoids showcase unique carbon skeletons featuring a common drimane sesquiterpene part with highly diverse polyketide units. Particularly, compound 1 incorporates a salicylic acid moiety while 2 possesses a rare peroxide bridge in the polyketide part. The structures of new compounds were assigned by extensive spectroscopic analysis, quantum calculations, and biogenetic considerations. Notably, 3 significantly blocked the mTOR signaling pathway, resulting in the arrest of cell cycle at G0‐G1 phase and triggering mitochondrial apoptosis in Hela cells. While the previously reported co‐metabolite macrophorin A (MPA) effectively triggered cell death in MDA‐MB‐231 cancer cells by activating apoptosis pathways involving death receptors, mitochondria, mTOR, and TNF.
Funder
National Key Research and Development Program of China
Xiamen Southern Oceanographic Center
National Natural Science Foundation of China