Affiliation:
1. Key Laboratory of Agri‐Food Safety of Anhui Province, School of Resources and Environment Anhui Agricultural University Hefei Anhui 230036 China
2. Key Laboratory of Green Pesticide and Agricultural Bio‐engineering, Ministry of Education Guizhou University Guiyang Guizhou 550025 China
3. College of Chemistry and Chemical Engineering Yantai University Yantai Shandong 264005 China
Abstract
Comprehensive SummaryA deuterated methylthiolating reagent with a broad spectrum, designated as DMTP, has been ingeniously formulated. This new reagent can be produced with high efficiency through the simple combination of commercially available methyl 3‐thiopropanoate and CD3I. This novel SCD3 reagent exhibits excellent reactivity with electrophiles such as alkyl iodides, benzyl chlorides, aryl halides (I, Br) and aryl triflates, resulting in high levels of deuterium content (99% D). Representative deuterated methylthiolated biomolecules, such as Sulfoxaflor, have been synthesized for use in pharmaceutical discovery and development.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Anhui Province