Affiliation:
1. Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen Shenzhen Guangdong 518057 China
2. National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based Medicine Shandong University Qingdao Shandong 266237 China
Abstract
Comprehensive SummaryProtein glycosylation is the most complex and diverse form of post‐translational modification in human body. Meanwhile, glycosylation of peptides and proteins emerges as a promising strategy to improve the pharmacokinetic profile of peptide‐ and protein‐based therapeutics. Owing to the importance of protein glycosylation, a rigorous evaluation of the relationship between the precise structure and biological function of glycoproteins has to be performed. Recently, chemical synthesis, chemoenzymatic synthesis and semisynthesis strategies have attracted extensive attentions towards the preparation of structurally defined glycopeptides and glycoproteins; the obtained synthetic glycoforms thus enable the thorough investigation of specific effects of protein glycosylation. This review highlights the recent progress in the development of novel strategies, preparation of homogeneous glycoproteins and exploration of structure‐activity relationships. On this basis, the challenges and prospects are discussed.
Funder
National Key Research and Development of China
National Natural Science Foundation of China
Shenzhen Fundamental Research Program
Cited by
1 articles.
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