A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data-Reference-Cited by-同舟云学术

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

Published:2019-09-23 Issue:10 Volume:8 Page:738-747
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Jones Hannah M.¹,Zhang Zhiwei²,Jasper Paul²,Luo Haobin²,Avery Lindsay B.³,King Lindsay E.⁴,Neubert Hendrik⁴,Barton Hugh A.⁵,Betts Alison M.¹,Webster Robert¹

Affiliation:

1. BioMedicine Design Pfizer Worldwide R&D Cambridge Massachusetts USA

2. RES Group Inc Needham Massachusetts USA

3. DMPK Sanofi Waltham Massachusetts USA

4. BioMedicine Design Pfizer Worldwide R&D Andover Massachusetts USA

5. BioMedicine Design Pfizer Worldwide R&D Groton Connecticut USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12461

Reference43 articles.

1. Antibodies to watch in 2018

2. Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

3. Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies

4. Prediction of Human Pharmacokinetics of Therapeutic Monoclonal Antibodies from Simple Allometry of Monkey Data

5. Interspecies Scaling of Therapeutic Monoclonal Antibodies: Initial Look

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows;mAbs;2024-07-31

2. An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies;Journal of Pharmacokinetics and Pharmacodynamics;2024-06-24

3. Translational two-pore PBPK model to characterize whole-body disposition of different-size endogenous and exogenous proteins;Journal of Pharmacokinetics and Pharmacodynamics;2024-05-01

4. Applications of machine learning in antibody discovery, process development, manufacturing and formulation: Current trends, challenges, and opportunities;Computers & Chemical Engineering;2024-03

5. A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics;Journal of Pharmacokinetics and Pharmacodynamics;2024-02-24