Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

Author:

Jansen Jeannette12,Knoll Jan12,Beyreuther Elke34,Pawelke Jörg35,Skuza Raphael12,Hanley Rachel12,Brons Stephan6,Pagliari Francesca1,Seco Joao12

Affiliation:

1. Division of Biomedical Physics in Radiation Oncology German Cancer Research Center (DKFZ) Heidelberg Germany

2. Faculty of Physics and Astronomy Ruprecht‐Karls‐University Heidelberg Germany

3. OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Helmholtz‐Zentrum Dresden–Rossendorf Dresden Germany

4. Helmholtz‐Zentrum Dresden–Rossendorf (HZDR) Institute of Radiation Physics Dresden Germany

5. Helmholtz‐Zentrum Dresden–Rossendorf (HZDR) Institute of Radiooncology‐OncoRay Dresden Germany

6. Heidelberg Ion‐Beam Therapy Center (HIT) Heidelberg Germany

Funder

Deutsche Forschungsgemeinschaft

Horizon 2020 Framework Programme

Publisher

Wiley

Subject

General Medicine

Reference27 articles.

1. Ultrahigh dose‐rate FLASH irradiation increases the differential response between normal and tumor tissue in mice;Vincent F;Sci Trans Med,2014

2. The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients

3. Impact of Target Oxygenation on the Chemical Track Evolution of Ion and Electron Radiation

4. Oxygen depletion in cells irradiated at ultra‐high dose‐rates and at conventional dose‐rates;Weiss H;Int J Radiat Biol,1974

5. Effect of High Dose Rates on Survival of Mammalian Cells

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