Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6‐Mediated Drug‐Drug Interactions on Tramadol and O‐Desmethyltramadol Exposures via Allosteric and Competitive Inhibition-Reference-Cited by-同舟云学术

Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6‐Mediated Drug‐Drug Interactions on Tramadol and O‐Desmethyltramadol Exposures via Allosteric and Competitive Inhibition

Published:2021-09-20 Issue:1 Volume:62 Page:76-86
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharma

Author:

Long Tao¹^ORCID,Cristofoletti Rodrigo¹,Cicali Brian¹^ORCID,Michaud Veronique²³^ORCID,Dow Pamela²^ORCID,Turgeon Jacques²³^ORCID,Schmidt Stephan¹

Affiliation:

1. Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USA

2. Tabula Rasa HealthCare Precision Pharmacotherapy Research and Development Institute Orlando Florida USA

3. Faculty of Pharmacy Université de Montréal Montréal Quebec Canada

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1951

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