NCI 8628: A randomized phase 2 study of ziv-aflibercept and high-dose interleukin 2 or high-dose interleukin 2 alone for inoperable stage III or IV melanoma

Author:

Tarhini Ahmad A.12,Frankel Paul3,Ruel Christopher3,Ernstoff Marc S.4,Kuzel Timothy M.5,Logan Theodore F.6,Khushalani Nikhil I.7,Tawbi Hussein A.8,Margolin Kim A.3,Awasthi Sanjay3,Butterfield Lisa H.191011,McDermott David12,Chen Alice13,Lara Primo N.14,Kirkwood John M.1

Affiliation:

1. University of Pittsburgh Medical Center Hillman Cancer Center; University of Pittsburgh; Pittsburgh Pennsylvania

2. Department of Hematology and Oncology; Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center; Cleveland Ohio

3. City of Hope National Medical Center; Duarte California

4. Roswell Park Comprehensive Cancer Center; Buffalo New York

5. Rush University Medical Center; Chicago Illinois

6. Indiana University Melvin and Bren Simon Cancer Center; Indianapolis Indiana

7. Moffitt Cancer Center; Tampa Florida

8. The University of Texas MD Anderson Cancer Center; Houston Texas

9. Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

10. Department of Surgery; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

11. Department of Immunology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

12. Beth Israel Deaconess Medical Center; Boston Massachusetts

13. Cancer Therapy Evaluation Program; National Cancer Institute; Bethesda Maryland

14. University of California at Davis Comprehensive Cancer Center; Sacramento California

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference30 articles.

1. Mutations of the BRAF gene in human cancer;Davies;Nature,2002

2. Immunotherapy of cancer in 2012;Kirkwood;CA Cancer J Clin,2012

3. Interleukin-2: inception, impact, and implications;Smith;Science,1988

4. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993;Atkins;J Clin Oncol,1999

5. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update;Atkins;Cancer J Sci Am,2000

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