Long COVID in Uganda: Electrographic findings among patients at risk

Author:

Semulimi Andrew Weil1ORCID,Batte Charles1,Iraguha Daniel2,Okwir Pamela Apio3,Atuhaire Hope4,Lipoto Chelsea5,Muwonge Tonny5,Namirembe Norah5,Lubega Grace Biyinzika5,Ainembabazi Provia6,Mukisa John7,Bongomin Felix8,Ssinabulya Isaac24,Okello Emmy24

Affiliation:

1. Lung Institute, Department of Medicine, School of Medicine College of Health Sciences, Makerere University Kampala Uganda

2. Division of Adult Cardiology Uganda Heart Institute Kampala Uganda

3. Clinical Epidemiology Unit, School of Medicine, College of Health Sciences Makerere University Kampala Uganda

4. Department of Medicine, School of Medicine, College of Health Sciences Makerere University Kampala Uganda

5. Department of Epidemiology and Biostatistics, School of Public Health College of Health Sciences, Makerere University Kampala Uganda

6. Department of Research Infectious Diseases Institute Kampala Uganda

7. Department of Molecular Biology and Immunology, School of Biomedical Sciences, College of Health Sciences Makerere University Kampala Uganda

8. Department of Medical Microbiology and Immunology Faculty of Medicine, Gulu University Gulu Uganda

Abstract

AbstractBackgroundCOVID‐19 has a significant cardiovascular involvement. An electrocardiographic (ECG) abnormalities among people at a risk of Long COVID in Uganda was investigated.MethodsA cross‐sectional study was conducted from February to June 2022 at the post COVID‐19 clinic in Mulago National Specialized Hospital, Kampala. A standard resting ECG was performed on individuals at least 2 months following acute COVID‐19, with a negative SARS‐CoV‐2 reverse‐transcription polymerase chain reaction. Socio‐demographic and clinical characteristics as well as vital signs were recorded for all study participants.ResultsOf the 244 study participants, 117 (47.9%) were female. The median age of all the participants was 33.0 (interquartile range: 26.0–43.5) years. Twenty‐five (10.2%) participants had a history of smoking, whereas 117 (48%) had a history of alcohol intake. In total, 46 (18.9%) had abnormal ECG findings (95% Confidence Interval [CI]: 14.39–24.29), and nonspecific T‐wave inversion (n = 16, 34%) was the most frequent ECG abnormality. The proportion of participants with ECG abnormalities was 48% lower among females (adjusted prevalence ratio [aPR]: 0.52, 95% CI: 0.28–0.96, p value <0.05) and twofold greater for those with a history of smoking (aPR: 2.03, 95% CI: 1.096–3.776, p value <0.05).ConclusionOne in five Ugandans who were checked at the clinic at a risk of Long COVID showed ECG abnormalities. ECG screening is suggested to be integrated into the follow‐up care of those at a risk of Long COVID.

Publisher

Wiley

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