Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells

Author:

Bame Eris1,Tang Hao2,Burns Jeremy C2ORCID,Arefayene Million1,Michelsen Klaus3,Ma Bin3,Marx Isaac3,Prince Robin3ORCID,Roach Allie M2ORCID,Poreci Urjana1,Donaldson Douglas1,Cullen Patrick2,Casey Fergal2,Zhu Jing2,Carlile Thomas M2,Sangurdekar Dipen2,Zhang Baohong2,Trapa Patrick3,Santoro Joseph3,Muragan Param3,Pellerin Alex2,Rubino Stephen2,Gianni Davide3,Bajrami Bekim3,Peng Xiaomei4,Coppell Alex5,Riester Katherine1,Belachew Shibeshih6,Mehta Devangi1,Palte Mike7,Hopkins Brian T3,Scaramozza Matthew7,Franchimont Nathalie7,Mingueneau Michael2ORCID

Affiliation:

1. Clinical Sciences Biogen Cambridge MA USA

2. Biogen Research Biogen Cambridge MA USA

3. Biotherapeutics and Medicinal Sciences Biogen Cambridge MA USA

4. Global Safety and Regulatory Sciences Biogen Cambridge MA USA

5. Clinical Operations Biogen Maidenhead UK

6. Personalized Health Research Biogen Baar Switzerland

7. MS Development Unit Biogen Cambridge MA USA

Funder

Biogen

Publisher

Wiley

Subject

General Nursing,Immunology,Immunology and Allergy

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