Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high‐dose clinical target volume in intensity‐modulated radiotherapy plan of nasopharyngeal carcinoma-Reference-Cited by-同舟云学术

Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high‐dose clinical target volume in intensity‐modulated radiotherapy plan of nasopharyngeal carcinoma

Published:2023-03 Issue:5 Volume:45 Page:1206-1214
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Qiu Zichen¹^ORCID,Lin Feifei¹^ORCID,Wu Zheng²,Wu Taihua³,Wang Mingli¹,Hu Jiang¹,Xie Dehuan⁴,Lyu Shaowen⁵,Ma Jun¹,Tao Yalan¹,Su Yong¹^ORCID

Affiliation:

1. Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China

2. Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China

3. School of Computer Science Zhuhai College of Science and Technology Zhuhai China

4. Department of Radiation Nasopharyngeal Carcinoma Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China

5. Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands

Abstract

AbstractBackgroundMost nasopharyngeal carcinoma (NPC) protocols define primary gross tumor volume (GTVnx) plus a range from 2 to 5 mm as the high‐dose clinical target volume (hd‐CTV). However, in China, hd‐CTV is defined as GTVnx plus 0 mm.MethodsA total of 40 patients with newly diagnosed nonmetastatic NPC (T1–T4 ten cases each) treated with IMRT were consecutively enrolled. Real and virtual treatment plans were designed according to the definitions of hd‐CTV recommended by China and Radiation Therapy Oncology Group (RTOG), respectively.ResultsThe hd‐CTV in China was significantly smaller than that of RTOG. Exposure doses to 5 mm subclinical involvement and OARs as well as NTCP in the China treatment plan were significantly lower than those of RTOG.ConclusionIt could be recommended to divide the hd‐CTV into GTV and subclinical target volume and to prescribe different doses for the GTV and subclinical involvement in the IMRT plan of NPC.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27334

Reference42 articles.

1. Prescribing recording and reporting photon beam therapy. International Commission on Radiation Units and Measurements (ICRU) report 50; 1993.

2. Prescribing Recording and Reporting Photon Beam Therapy. International Commission on Radiation Units and Measurements (ICRU) report 62 (Supplement to ICRU 50); 1999.

3. Prescribing recording and reporting electron beam therapy. International Commission on Radiation Units and Measurements (ICRU) report 71; 2004.

4. Prescribing Recording and Reporting Proton‐Beam Therapy. International Commission on Radiation Units and Measurements (ICRU) report 78; 2007.

5. Prescribing recording and reporting intensity‐modulated photon‐beam therapy (IMRT). International Commission on Radiation Units and Measurements (ICRU) report 83; 2010.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Embracing Personalized Strategies in Radiotherapy for Nasopharyngeal Carcinoma: Beyond the Conventional Bounds of Fields and Borders;Cancers;2024-01-16