Affiliation:
1. Tata Memorial Centre, Advanced Centre for Treatment, Education and Research in Cancer Navi Mumbai Maharashtra India
2. Training School Complex, Homi Bhabha National Institute Anushakti Nagar Maharashtra India
3. Centre for Interdisciplinary Research D.Y. Patil University Navi Mumbai Maharashtra India
Abstract
AbstractBackgroundLoco‐regional recurrences attributable to field cancerization and minimal residual cancer, remain prime causes of mortality in oral cancer (OC) subjects. The current study evaluates potential of serum Raman spectroscopy (SRS) to identify recurrence‐prone OC subjects.MethodsRaman spectra of serum from eight healthy subjects (H) and 57 OC subjects (with‐recurrence [R], without‐recurrence [NR], and with suspicious‐lesions [S]), before (BS) and after (AS) surgical excision of tumor were recorded. OC subjects were followed‐up for 7‐years.ResultsDNA and protein alterations were observed in AS sera of all groups. 4‐, 3‐, and 2‐model multivariate analyses were used to stratify BS and AS groups. H spectra were 100% distinguishable from all other groups. AS, R and NR were distinguished with high accuracy (84%) in all models. No stratification (~50%) was observed BS.ConclusionSRS shows potential to identify recurrence prone subjects, post‐surgery, using serum collected as early as 1 week after surgery.
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