Affiliation:
1. Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province School of Basic Medical Science Cheeloo College of Medicine Shandong University Jinan Shandong China
Abstract
AbstractThe NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome is a multimolecular complex that plays a fundamental role in inflammation. Optimal activation of NLRP3 inflammasome is crucial for host defense against pathogens and the maintenance of immune homeostasis. Aberrant NLRP3 inflammasome activity has been implicated in various inflammatory diseases. Posttranslational modifications (PTMs) of NLRP3, a key inflammasome sensor, play critical roles in directing inflammasome activation and controlling the severity of inflammation and inflammatory diseases, such as arthritis, peritonitis, inflammatory bowel disease, atherosclerosis, and Parkinson's disease. Various NLRP3 PTMs, including phosphorylation, ubiquitination, and SUMOylation, could direct inflammasome activation and control inflammation severity by affecting the protein stability, ATPase activity, subcellular localization, and oligomerization of NLRP3 as well as the association between NLRP3 and other inflammasome components. Here, we provide an overview of the PTMs of NLRP3 and their roles in controlling inflammation and summarize potential anti‐inflammatory drugs targeting NLRP3 PTMs.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Academy of Medical Sciences
Subject
Immunology,Immunology and Allergy
Cited by
1 articles.
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