Allergic sensitisation and type‐2 inflammation is associated with new‐onset and persistent allergic disease

Author:

Blöndal Viiu1ORCID,Sundbom Fredrik1,Zhou Xingwu12,Movérare Robert13,Borres Magnus P.34,Högman Marieann1,Alving Kjell4,Malinovschi Andrei12ORCID,Janson Christer1

Affiliation:

1. Department of Medical Sciences, Respiratory, Allergy and Sleep Research Uppsala University Uppsala Sweden

2. Department of Medical Sciences Clinical Physiology Uppsala University Uppsala Sweden

3. Thermo Fischer Scientific Uppsala Sweden

4. Department of Women's and Children's Health Uppsala University Uppsala Sweden

Abstract

AbstractBackgroundAllergic disease is common. The aim of this study was to look at the change in asthma and rhinitis over time and to characterise factors contributing to remission and persistence of disease.MethodsThis cohort study included 255 individuals with or without asthma and or rhinitis that participated in a population survey and a follow‐up 10 years later. The participants were tested for allergic sensitisation, total IgE, multiplex allergen component analysis and type‐2 inflammatory markers: exhaled nitric oxide (FENO), eosinophil cationic protein (ECP) and eosinophil‐derived neurotoxin (EDN).ResultsOf the 132 healthy individuals, 112 remained healthy, 16 developed rhinitis, 4 asthma and rhinitis over the 10 years. Out of 82 subjects with rhinitis, 26 went into remission, 53 remained unchanged and 3 developed asthma in addition to rhinitis. None of the 41 participants with asthma and rhinitis went into remission. Subjects with persistent rhinitis and asthma had higher levels of total IgE (odds ratio [OR] 95% confidence interval [CI]: 6.16 [3.05–12.5]) at baseline and after 10 years, and FENO and ECP at baseline (OR per log unit increase, 95% CI 5.21 [1.20–22.7] and 6.32 [1.52–26.4], respectively), compared with those that remained healthy. Subjects with persistent rhinitis were more likely to be sensitised to grass pollen and had higher total IgE levels than those that went into remission. Individuals with persistent asthma were more likely to be sensitised to tree pollen and furry animals than those with only persistent rhinitis (OR 95% CI: 3.50 [1.29–9.49] and 6.73 [2.00–22.6], respectively).ConclusionIgE sensitisation and total IgE levels are associated with the persistence of rhinitis and asthma. Participants with persistent allergic disease had higher levels of allergen sensitisation and type 2 inflammation markers at baseline than those who remained healthy.

Publisher

Wiley

Subject

Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3