A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative

Author:

Zuberbier Torsten12ORCID,Abdul Latiff Amir3,Aggelidis Xenofon4ORCID,Augustin Matthias56,Balan Radu‐Gheorghe7,Bangert Christine8,Beck Lisa9,Bieber Thomas1011,Bernstein Jonathan A.12,Bertolin Colilla Marta13,Berardi Alejandro14,Bedbrook Anna15,Bindslev‐Jensen Carsten16ORCID,Bousquet Jean17ORCID,de Bruin‐Weller Marjolein18,Bruscky Dayanne19,Buyuktiryaki Betul20ORCID,Canonica Giorgio Walter21,Castro Carla22,Chanturidze Natia23,Chong‐Neto Herberto Jose17,Chu Chia‐Yu24,Chularojanamontri Leena25,Cork Michael26,Criado Roberta F. J.2728ORCID,Barredo Laia Curto29,Custovic Adnan30,Darsow Ulf31,Emurlai Arben32,de Pablo Ana33,Del Giacco Stefano34,Girolomoni Giampiero35,Deleva Jovanova Tanja36,Deleuran Mette37,Douladiris Nikolaos4,Duarte Bruno38,Dubakiene Ruta39,Eller Esben16,Engel‐Yeger Batya40,Ensina Luis Felipe41,Filho Nelson Rosario17,Flohr Carsten42,Fomina Daria43,Francuzik Wojciech44,Galimberti Maria Laura45,Giménez‐Arnau Ana M.46ORCID,Godse Kiran47,Mortz Charlotte Gotthard16,Gotua Maia23,Hide Michihiro48,Hoetzenecker Wolfram49,Hunzelmann Nicolas50,Irvine Alan51,Jack Carolyn52,Kanavarou Ioanna4,Katoh Norito53,Kinaciyan Tamar8,Kocatürk Emek20,Kulthanan Kanokvalai25,Lapeere Hilde54,Lau Susanne55,Machado Forti Nastri Mariana56,Makris Michael4,Mansour Eli57ORCID,Marsland Alexander58,Morelo Rocha Felix Mara59,Moschione Castro Ana Paula60,Nettis Eustachio61,Nicolas J. F.62,Nosbaum Audrey6364,Odemyr Mikaela6566,Papapostolou Niki4,Parisi Claudio A. S.46,Paudel Sushil67,Peter Jonny6869ORCID,Pokharel Prakash7071,Puig Luis72,Quint Tamara8,Ramon German Dario7071,Regateiro Frederico73,Ricci Giampaolo74,Rosario Cristine75,Sackesen Cansin20,Schmid‐Grendelmeier Peter7677,Serra‐Baldrich Esther64,Siemens Kristina78,Smith Cathrine79,Staubach Petra80,Stevanovic Katarina12,Su‐Kücük Özlem81,Sussman Gordon82,Tavecchio Simona83,Teovska Mitrevska Natasa84,Thaci Diamant85,Toubi Elias86,Traidl‐Hoffmann Claudia87,Treudler Regina88,Vadasz Zahava89,van Hofman Ingrid90,Ventura Maria Teresa91,Wang Zhao92,Werfel Thomas93,Wollenberg Andreas9495,Yang Ariana9697,Weng Yew Yik98,Zhao Zuotao99ORCID,Zwiener Ricardo100ORCID,Worm Margitta56ORCID

Affiliation:

1. Institute of Allergology Charité ‐ Universitätsmedizin Berlin Berlin Germany

2. Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Berlin Germany

3. Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia

4. Allergy Unit 2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens University General Hospital "Attikon" Athens Greece

5. University Medical Center Hamburg‐Eppendorf Hamburg Germany

6. Institute for Health Services Research in Dermatology and Nursing Hamburg Germany

7. Institutul Regional de Gastroenterologie si Hepatologie Cluj‐Napoca Romania

8. Department of Dermatology Medical University of Vienna Vienna Austria

9. University of Rochester Medical Center Rochester New York USA

10. University Hospital of Bonn Bonn Germany

11. Christine Kühne‐Center of Allergy Research and Education Davos Switzerland

12. University of Cincinnati College of Medicine Cincinnati Ohio USA

13. Hospital del Mar Barcelona Spain

14. Instituto de Asma Alergia y Enfermedades Respiratorias Corrientes Argentina

15. MACVIA‐France Fondation Partenariale FMC VIA‐LR Montpellier France

16. Department of Dermatology and Allergy Centre Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark Odense C Denmark

17. Division of Allergy and Immunology Complexo Hospital de Clinicas Federal University of Paraná Curitiba Brazil

18. Department of Dermatology/Allergology National Expertise Center for Atopic Dermatitis University Medical Center Utrecht Utrecht The Netherlands

19. Federal University of Pernambuco Recife Brazil

20. Division of Pediatric Allergy Koc University Hospital Istanbul Turkey

21. Personalized Medicine, Asthma and Allergy IRCCS Humanitas Research Hospital Rozzano, Milan Italy

22. Department of Dermatology Hospital Universitario Austral Universidad Austral Buenos Aires Argentina

23. Center of Allergy and Immunology Tbilisi Georgia

24. Department of Dermatology National Taiwan University Hospital Taipei Taiwan

25. Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand

26. Sheffield Dermatology Research IICD University of Sheffield Sheffield UK

27. Alergoskin Alergia e Dermatologia Santo Andre Brazil

28. Department of Dermatology Centro Universitario FMABC Santo Andre Brazil

29. Hospital del Mar Parc de Salut Mar Barcelona Spain

30. National Heart and Lung Institute Imperial College London UK

31. Department of Dermatology and Allergy Biederstein Technische Universität München Munich Germany

32. Clinical Hospital Tetovo Tetovo North Macedonia

33. Hospital Universitario Austral Pilar Argentina

34. Allergy and Clinical Immunology University of Cagliari Sardinia Italy

35. Section of Dermatology Department of Medicine University of Verona Verona Italy

36. Health Center Skoplje Skoplje North Macedonia

37. Department of Dermatology Aarhus University Hospital Aarhus Denmark

38. Hospital Santo Antonio dos Capuchos Centro Universitário de Lisboa Central Lisbon Portugal

39. Department of Immunology and Allergology Medical Faculty Clinics of Chest Diseases Vilnius University Vilnius Lithuania

40. Occupational Therapy Department Faculty of Social Welfare and Health Sciences University of Haifa Haifa Israel

41. CPAlpha Clinical Research Center Barueri – São Paulo Brazil

42. St John's Institute of Dermatology St Thomas' Hospital London UK

43. Center of Allergy and Immunology Clinical State Hospital 52 Moscow Ministry of Healthcare Moscow Russian Federation

44. Division of Allergy and Immunology Department of Dermatology, Venereology and Allergology Charité – Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

45. Hospital Italiano de Buenos Aires Buenos Aires Argentina

46. Dermatology Department Hospital del Mar IMIM Universitat Autonoma y Universitat Pompeu Fabra Barcelona Spain

47. D.Y. Patil University Navi Mumbai Maharashtra India

48. Department of Dermatology Hiroshima University Hospital Hiroshima Japan

49. Department of Dermatology Kepler University Hospital Linz Austria

50. Department of Dermatology University of Cologne Cologne Germany

51. Clinical Medicine Trinity College Dublin Dublin Ireland

52. Research Institute of the McGill University Health Centre Montreal Quebec Canada

53. Department of Dermatology Kyoto Prefectural University of Medicine Kyoto Japan

54. Ghent University Hospital Ghent Belgium

55. Charité‐Universitätsmedizin Berlin Berlin Germany

56. Faculdade de Medicina Hospital das Clínicas Instituto da Criança e do Adolescente Universidade de São Paulo São Paulo Brazil

57. Division of Allergy and Immunology Department of Clinical Medicine University of Campinas Campinas Brazil

58. Salford Royal Foundation Trust ‐ University of Manchester and Spire Manchester Hospital Manchester UK

59. AlergoLife Clinici Rio de Janeiro Brazil

60. Instituto da Criança Rio de Janeiro Brazil

61. Department of Emergency and Organ Transplantation School and Chair of Allergology and Clinical Immunology University of Bari ‐ Aldo Moro Bari Italy

62. Department of Clinical Immunology and Allergy Lyon‐Sud University Hospital CIRI/INSERM U1111 Lyon France

63. Service d'Allergologie et Immunologie Clinique Centre Hospitalier Lyon Sud Hospices Civils de Lyon Pierre‐Bénite France

64. Centre International de Recherche en Infectiologie INSERM U1111 CNRS UMR 5308 UCBL1 ENS de Lyon Lyon France

65. EFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium

66. President of the Swedish Asthma and Allergy Association Stockholm Sweden

67. Center Civil Service Hospital Kathmandu Nepal

68. Division of Allergy and Clinical Immunology Department of Medicine University of Cape Town Cape Town South Africa

69. Allergy and Immunology Unit University of Cape Town Lung Institute Cape Town South Africa

70. Instituto de Alergia e Inmunologia del Sur Bahia Blanca Buenos Aires Argentina

71. Allergia e Inmunologia Section Hospital Italiano Regional del Sur Bahia Blanca Buenos Aires Argentina

72. Department of Dermatology Hospital de la Santa Creu i Sant Pau Barcelona Spain

73. Centro Hospitalar Universitário de Coimbra Coimbra Portugal

74. Department of Medical and Surgical Sciences DIMEC University of Bologna Bologna Italy

75. Federal University of Parana Curitiba Brazil

76. Department of Dermatology Allergy Unit University Hospital of Zürich Zürich Switzerland

77. Chrstine Kèhne Center for Allergy Research and Education CK_CARE Davos Switzerland

78. King's College London London UK

79. St John's Institute of Dermatology Guys and St Thomas' NHS Trust London UK

80. Department of Dermatology and Allergy Hautklinik und Poliklinik der Universitätsmedizin University Medical Center Mainz Germany

81. Department of Dermatology Faculty of Medicine Bezmialem Vakif University Istanbul Turkey

82. Faculty of Medicine University of Toronto Toronto Ontario Canada

83. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy

84. ReMedika General Hospital Skopje North Macedonia

85. Center for Comprehensive Inflammation Medicine University of Lübeck Lübeck Germany

86. Allergy and Clinical Immunology Holy Family Hospital Nazareth Israel

87. Environmental Medicine Faculty of Medicine University of Augsburg Augsburg Germany

88. Universtiy Leipzig Medical Faculty Leipziger Interdisziplinäres Centrum für Allergologie Leipzig Germany

89. Bnai‐Zion Medical Center Haifa Israel

90. GA2LEN Network Berlin Germany

91. University of Bari Aldo Moro Bari Italy

92. Department of Dermatology Second Affiliated Hospital Northwest Hospital Xi'an Jiaotong University Xi'an Shaanxi China

93. Department of Dermatology and Allergy Hannover Medical School Hannover Germany

94. Department of Dermatology and Allergy Ludwig‐Maximilian‐University Munich Germany

95. Department of Dermatology Free University Brussels University Hospital Brussels Brussels Belgium

96. Division of Allergy and Clinical Immunology of University of Sao Paulo São Paulo Brazil

97. Faculty of Medical Sciences of UNICAMP São Paulo Brazil

98. National Skin Centre Singapore Singapore

99. Department of Dermatology First Hospital Peking University Beijing China

100. Medicina Interna y Alergología e Inmunología Clínica Hospital Universitario Austral Pilar Argentina

Abstract

AbstractIntroductionThe integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co‐ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems.MethodsThe GA2LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD‐ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL2EN ADCARE centres.ResultsThe AD‐ICPs outline the diagnostic procedures, possible co‐morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD.ConclusionThe AD‐ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD.

Publisher

Wiley

Subject

Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine

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