The Lipophilic Vitamin C Derivative, 6-O-Palmitoylascorbate Protects Human Keratinocytes and 3D-Human Skin Equivalents Against X-Ray-Induced Oxidative Stress and Apoptosis More Markedly Than L-Ascorbic Acid

Author:

Xiao Li1,Miwa Nobuhiko2

Affiliation:

1. Department of Pharmacology, School of Life Dentistry at Tokyo; Nippon Dental University; 1-9-20 Fujimi, Chiyoda-ku Tokyo 102-8159 Japan

2. Faculty of Health Sciences, Department of Radiological Technology; Butsuryo College of Osaka; Otorikitamachi 3-33, Nishi-ku, Sakai Osaka 593-8328 Japan

Funder

Japanese Center for AntiAging MedSciences, Hiroshima, Japan

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference28 articles.

1. Lipid peroxidation: Control of cell proliferation, cell differentiation and cell death;Barrera;Mol Aspects Med,2008

2. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line;Boukamp;J Cell Biol,1988

3. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance;Burgess;Proc Natl Acad Sci USA,2010

4. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes;Celli;Am J Physiol,1998

5. Radioprotectors and mitigators of radiation-induced normal tissue injury;Citrin;Oncologist,2010

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