Salting‐out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high‐performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Author:

Meirinho Sara1,Campos Gonçalo1,Rodrigues Márcio12ORCID,Fortuna Ana34,Falcão Amílcar34,Alves Gilberto1ORCID

Affiliation:

1. CICS‐UBI – Health Sciences Research Center University of Beira Interior Covilhã Portugal

2. UDI‐IPG – Research Unit for Inland Development Polytechnic Institute of Guarda Guarda Portugal

3. Laboratory of Pharmacology Faculty of Pharmacy University of Coimbra Coimbra Portugal

4. CIBIT/ICNAS – Coimbra Institute for Biomedical Imaging and Translational Research University of Coimbra Coimbra Portugal

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference49 articles.

1. Stiripentol for the treatment of seizures associated with Dravet syndrome

2. European Medicines Agency Stiripentol (Diacomit). Summary of product characteristics.https://www.ema.europa.eu/en/documents/product-information/diacomit-epar-product-information_en.pdf(last time accessed: August 15 2020).

3. Stiripentol in the Management of Epilepsy

4. Pharmacodynamics and common drug-drug interactions of the third-generation antiepileptic drugs

5. Stiripentol add‐on therapy for focal refractory epilepsy;Brigo F;Cochrane Database Syst Rev,2018

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