Mechanistic modeling and simulation of a complex low and high loading elution behavior of a polypeptide in cation exchange chromatography-Reference-Cited by-同舟云学术

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Mechanistic modeling and simulation of a complex low and high loading elution behavior of a polypeptide in cation exchange chromatography

Published:2022-04-06 Issue:12 Volume:45 Page:2008-2023
ISSN:1615-9306
Container-title:Journal of Separation Science
language:en
Short-container-title:J of Separation Science

Author:

Koch Jonas¹^ORCID,Scheps Daniel²,Gunne Matthias³,Boscheinen Oliver²,Hafner Mathias⁴,Frech Christian¹^ORCID

Affiliation:

1. Institute for Biochemistry University of Applied Sciences Mannheim Germany

2. CMC Microbial Platform Sanofi‐Aventis Deutschland GmbH Frankfurt am Main Germany

3. IA MSAT M&I DS Sanofi‐Aventis Deutschland GmbH Frankfurt am Main Germany

4. Institute of Molecular Biology and Cell Culture Technology University of Applied Sciences Mannheim Germany

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jssc.202200098

Reference54 articles.

1. Biopharmaceuticals from microorganisms: from production to purification

2. Quality by design for biopharmaceuticals

3. Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

4. Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient

5. Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

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1. Enhancing thermodynamic consistency: Clarification on the application of asymmetric activity model in multi-component chromatographic separation;Journal of Chromatography A;2024-08

2. Current state of implementation of in silico tools in the biopharmaceutical industry—Proceedings of the 5th modeling workshop;Biotechnology and Bioengineering;2024-06-10

3. Standardized approach for accurate and reliable model development of ion‐exchange chromatography based on parameter‐by‐parameter method and consideration of extra‐column effects;Biotechnology Journal;2024-03

4. Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review;Journal of Chromatography A;2024-02

5. Separation of proteins by ion-exchange chromatography;Ion-Exchange Chromatography and Related Techniques;2024

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