Cyclodextrin‐NH‐MIL‐53 open tubular stationary phase for capillary electrochromatography enantioseparation

Author:

Zheng Xiangtai1ORCID,Wu Guihua2,Yang Zhihao3,Guo Na3,Niu Bing3,Chen Qin3,Sun Xiaodong1ORCID

Affiliation:

1. Shanghai Engineering Research Center of Organ Repair School of Medicine Shanghai University Shanghai P. R. China

2. Geriatric Department The Sixth People's Hospital of Nantong Nantong P. R. China

3. School of Life Science Shanghai University Shanghai P. R. China

Abstract

A novel chiral group functionalized metal‐organic framework, Cyclodextrin‐NH‐MIL‐53, was synthesized and modified on the inner wall of a capillary column via a post‐synthetic process. The prepared chiral metal‐organic framework was utilized as a chiral capillary stationary phase and used in an open‐tubular capillary electrochromatography method to enantioseparate several racemic amino acids. Excellent enantioseparation of five pairs of enantiomers was obtained in this chiral separation system (Resolutions of D/L‐Alanine = 16.844, D/L‐Cysteine = 3.617, D/L‐Histidine = 9.513, D/L‐Phenylalanine = 8.133, and D/L‐Tryptophan = 2.778). The prepared Cyclodextrin‐NH‐MIL‐53 and the Cyclodextrin‐NH‐MIL‐53‐based capillary columns were characterized by scanning electron microscopy, X‐ray diffraction, Fourie‐transform infrared spectroscopy, and circular dichroism. The chiral capillary electrochromatography conditions, such as separation conditions, amount of Cyclodextrin‐NH‐MIL‐53, and electroosmotic flow, were optimized. This research is estimated to present a novel insight and method for the design and use of metal‐organic framework‐based capillaries for enantioseparation.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3