A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor-Reference-Cited by-同舟云学术

A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

Published:2021-09-09 Issue:21 Volume:44 Page:3959-3966
ISSN:1615-9306
Container-title:Journal of Separation Science
language:en
Short-container-title:J. Sep. Sci.

Author:

Zhou Jun¹,Zhan Yan²,Zhong Dafang²,Chen Xiaoyan²,Zhang Yifan²,Zhang Qi¹,Bo Yunhai³,Shen Lin¹,Gong Jifang¹,Li Jian¹,Yang Fen³^ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute Beijing P. R. China

2. State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai P. R. China

3. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) National Drug Clinical Trial Center Peking University Cancer Hospital & Institute Beijing P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jssc.202100491

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1. A Phase Ib Study of the Simmitecan Single Agent and in Combination With 5-Fluorouracil/Leucovorin or Thalidomide in Patients With Advanced Solid Tumor;Frontiers in Pharmacology;2022-07-22

2. Target profiling of flavonol glycosides in the extract of Ginkgo biloba leaf and their pharmacokinetics in rat plasma by ultra‐high‐performance liquid chromatography with tandem mass spectrometry;Journal of Separation Science;2021-12-08