Recent advances of optically active helical polymers as adsorbents and chiral stationary phases for chiral resolution

Author:

Yuan Shuyi1,Zhao Lei1,Wang Fangqin1,Tan Lilan1,Wu Datong12ORCID

Affiliation:

1. Jiangsu Key Laboratory of Advanced Materials and Technology School of Petrochemical Engineering Changzhou University Changzhou P. R. China

2. Department of Molecular and Macromolecular Chemistry Graduate School of Engineering Nagoya University Nagoya Japan

Abstract

Chiral resolution is very important and still a big challenge due to different biological activity and same physicochemical property of one pair (R)‐ and (S)‐isomer. There is no doubt that chiral selectors are essentially needed for chiral resolution, which can stereoselectively interact with a pair of isomers. To date, a large amount of optically active helical polymers as chiral selectors have been synthesized via two strategies. First, the target helical polymers are derived from natural polysaccharide such as cellulose and amylose. Second, they can be synthesized by polymerization of chiral monomers. Alternatively, an achiral polymer is prepared first followed by static or dynamic chiral induction. Furthermore, a part of them is harnessed as chiral stationary phases for chromatographic chiral separation and as chiral adsorbents for enantioselective adsorption/crystallization, resulting in good enantioseparation efficiency. In summary, the present review will focus on recent progress of the polymers with optical activity for chiral resolution, especially the literature published in the past 10 years. In addition, development prospects and future challenges of optically active helical polymers will be discussed in detail.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

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