Review of recent advances in development and applications of organic‐silica hybrid monoliths

Abstract

Organic‐silica hybrid monoliths attracted attention as an alternative to extensively researched organic polymer‐based and silica‐based counterparts. The development and applications of these materials as extraction and separation media in capillary liquid chromatography and capillary electrochromatography were previously reviewed in several manuscripts. In this review, we will concentrate on work published since mid‐2016 focusing on advances in their development using sol‐gel chemistry of tetra‐ and trialkoxysilanes and subsequent surface modification with organic monomers, and “one‐pot” strategy incorporating sol‐gel chemistry of alkoxysilanes and free‐radical polymerization, ring‐opening polymerization, or thiol‐based click polymerization with organic monomers. Approaches adapted to the preparation of hybrid monoliths made with polyhedral oligomeric silsesquioxanes will be covered as well.