Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resource

Author:

Nguyen Hiep Tai1,Tang Weiliang1,Webster Andrew L. H.2,Whiteaker Jeffrey R.3,Chandler Christopher M.1,Errazquin Ricardo45,Roohollahi Khashayar6,Fritzke Madeline1,Hoskins Elizabeth E.6,Jonlin Erica17,Wakefield Leslie8,Sullivan Lucas B.9,Chen Eleanor Y.1,Dorsman Josephine6,Brakenhoff Ruud6,Paulovich Amanda G.3,Grompe Markus8,Garcia‐Escudero Ramon4510ORCID,Wells Susanne I.11ORCID,Smogorzewska Agata2,Monnat Raymond J.112ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology University of Washington Seattle Washington USA

2. Laboratory of Genome Maintenance Rockefeller University New York New York USA

3. Fred Hutchinson Cancer Center, Clinical Research Division Seattle Washington USA

4. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12) Madrid Spain

5. Biomedical Oncology Unit, CIEMAT (Centro de Investigaciones Energéticas, Medio‐ambientales y Tecnológicas) Madrid Spain

6. Amsterdam University Medical Center Amsterdam The Netherlands

7. University of Washington Institute for Stem Cell and Regenerative Medicine Seattle Washington USA

8. Departments of Pediatrics and Molecular and Medical Genetics Oregon Health and Sciences University Portland Oregon USA

9. Fred Hutchinson Cancer Center, Human Biology Division Seattle Washington USA

10. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid Spain

11. Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

12. Department of Genome Sciences University of Washington Seattle Washington USA

Abstract

AbstractFanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of squamous carcinomas. These carcinomas originate in epithelia lining the mouth, proximal esophagus, vulva and anus: their origins are not understood, and no effective ways have been identified to prevent or delay their appearance. Many FA‐associated carcinomas are also therapeutically challenging: they may be multi‐focal and stage‐advanced at diagnosis, and most individuals with FA cannot tolerate standard‐of‐care systemic therapies such as DNA cross‐linking drugs or ionizing radiation due to constitutional DNA damage hypersensitivity. We developed the Fanconi Anemia Cancer Cell Line Resource (FA‐CCLR) to foster new work on the origins, treatment and prevention of FA‐associated carcinomas. The FA‐CCLR consists of Fanconi‐isogenic head and neck squamous cell carcinoma (HNSCC) cell line pairs generated from five individuals with FA‐associated HNSCC, and five individuals with sporadic HNSCC. Sporadic, isogenic HNSCC cell line pairs were generated in parallel with FA patient‐derived isogenic cell line pairs to provide comparable experimental material to use to identify cell and molecular phenotypes driven by germline or somatic loss of Fanconi pathway function, and the subset of these FA‐dependent phenotypes that can be modified, complemented or suppressed. All 10 FANC‐isogenic cell line pairs are available to academic, non‐profit and industry investigators via the “Fanconi Anemia Research Materials” Resource and Repository at Oregon Health & Sciences University, Portland OR.

Funder

Fanconi Anemia Research Fund

V Foundation for Cancer Research

Publisher

Wiley

Subject

Cancer Research,Oncology

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