Survival and pulmonary function in stage IA non‐small cell lung cancer after sublobar resection versus lobectomy: An updated meta‐analysis-Reference-Cited by-同舟云学术

Survival and pulmonary function in stage IA non‐small cell lung cancer after sublobar resection versus lobectomy: An updated meta‐analysis

Published:2024-07-09 Issue: Volume: Page:
ISSN:0022-4790
Container-title:Journal of Surgical Oncology
language:en
Short-container-title:Journal of Surgical Oncology

Author:

Mamede Isadora¹^ORCID,Ribeiro Leonardo²,Stecca Carlos³,Escalante‐Romero Lorena⁴,Cypel Marcelo⁵

Affiliation:

1. Department of Medicine Federal University of Sao Joao del‐Rei Divinopolis Brazil

2. Department of Medicine Pontifical Catholic University of Sao Paulo São Paulo Brazil

3. Department of Medical Oncology Mackenzie Evangelical University Hospital Curitiba Brazil

4. Department of Pediatric Oncology Federal University of Sao Paulo Sao Paulo Brazil

5. Department of Surgery University of Toronto Toronto Ontario Canada

Abstract

AbstractTraditionally, lobectomy was standard for stage IA non‐small‐cell lung cancer (NSCLC). Recent RCTs suggest sublobar resection's comparable outcomes. Our meta‐analysis, incorporating 30 studies (including four RCTs), assessed sublobar resection's efficacy. Employing a random‐effects model and I2 statistics for heterogeneity, we found sublobar resection reduced DFS (HR 1.31, p < 0.01) and OS (HR 1.27, p < 0.01) overall. However, RCT subgroup analysis showed no significant differences in DFS (p = 0.28) or OS (p = 0.62). Sublobar resection is a viable option for well‐selected patients.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jso.27767

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