Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait-Reference-Cited by-同舟云学术

Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait

Published:2023-05-26 Issue:3 Volume:4 Page:705-709
ISSN:2688-6146
Container-title:eJHaem
language:en
Short-container-title:eJHaem

Author:

Gomes Ingrid Cristiane Pereira¹²³^ORCID,Magalhães Lucas Sousa¹⁴⁵^ORCID,Bomfim Lays Gisele Santos¹^ORCID,dos Santos Priscila Lima¹⁴⁶^ORCID,Silva Roberto Jerônimo dos Santos⁷^ORCID,Cruz Maria Carollyne Passos¹⁸^ORCID,de Albuquerque Lindemberg Costa³^ORCID,Neves Victoria Haydée Deusdedith³^ORCID,de Oliveira Paula Gabriella Pereira Rosa⁸^ORCID,Carvalho Alessandro Freire⁹^ORCID,Silva Lucas Oliveira²^ORCID,Aragão Matheus Todt¹^ORCID,Moura Tatiana Rodrigues¹⁵¹⁰^ORCID,Cipolotti Rosana¹²^ORCID

Affiliation:

1. Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil

2. Department of Medicine Federal University of Sergipe Aracaju Sergipe Brazil

3. Department of Medicine Tiradentes University Aracaju Sergipe Brazil

4. Laboratory of Molecular Biology and Immunology Federal University of Sergipe Aracaju Sergipe Brazil

5. Sector of Parasitology and Pathology Biological and Health Sciences Institute Federal University of Alagoas Maceió Alagoas Brazil

6. Department of Health Education Federal University of Sergipe Lagarto Sergipe Brazil

7. Department of Physical Education Federal University of Sergipe, São Cristóvão, Sergipe, Brazil São Cristóvão Sergipe Brazil

8. Department of Nutrition Federal University of Sergipe Lagarto Sergipe Brazil

9. Department of Nutrition Tiradentes University Aracaju Sergipe Brazil

10. Department of Morphology Federal University of Sergipe São Cristóvão Sergipe Brazil

Abstract

AbstractAlthough sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross‐sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL‐1β, IL‐6, IL‐10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL‐8/IL‐10 and soluble triggering receptor expressed on myeloid cells‐1/IL‐10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.

Publisher

Wiley

Subject

General Earth and Planetary Sciences

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jha2.712

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