Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors-Reference-Cited by-同舟云学术

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors

Published:2017-04 Issue:3 Volume:38 Page:187-208
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Hatley Oliver J.D.¹²,Jones Christopher R.³,Galetin Aleksandra²,Rostami-Hodjegan Amin¹²^ORCID

Affiliation:

1. Certara; Blades Enterprise Centre; Sheffield S2 4SU UK

2. Centre for Applied Pharmacokinetic Research; University of Manchester; Manchester M13 9PT UK

3. DMPK; Heptares Therapeutics; Welwyn Garden City AL7 3AX UK

Funder

Medical Research Council

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference56 articles.

1. First-pass elimination. Basic concepts and clinical consequences;Pond;Clin Pharmacokinet,1984

2. ADMET in silico modelling: towards prediction paradise?;Waterbeemd;Nat Rev Drug Discov,2003

3. Gut wall metabolism. Application of pre-clinical models for the prediction of human drug absorption and first-pass elimination;Jones;AAPS J,2016

4. Is the role of the small intestine in first-pass metabolism overemphasized?;Lin;Pharmacol Rev,1999

5. Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations;Gertz;Curr Drug Metab,2008a

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design;CPT: Pharmacometrics & Systems Pharmacology;2024-02-14

2. Use of Human Intestinal and Hepatic Tissue Fractions and Microbiome as Models in Assessment of Drug Metabolism and its Impact on Oral Bioavailability;Oral Bioavailability and Drug Delivery;2023-10-10

3. Effects of aqueous extract from Baiyedancong-Oolong tea on cytochrome P450 enzymes activities, P-gp and OATs transport abilities and transcription levels in mice;Frontiers in Nutrition;2023-05-09

4. The Interplay Between Drug Release and Intestinal Gut‐Wall Metabolism;Oral Drug Delivery for Modified Release Formulations;2022-04-08

5. Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics;Drug Metabolism and Disposition;2021-09-21