Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors
Author:
Affiliation:
1. Certara; Blades Enterprise Centre; Sheffield S2 4SU UK
2. Centre for Applied Pharmacokinetic Research; University of Manchester; Manchester M13 9PT UK
3. DMPK; Heptares Therapeutics; Welwyn Garden City AL7 3AX UK
Funder
Medical Research Council
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine
Reference56 articles.
1. First-pass elimination. Basic concepts and clinical consequences;Pond;Clin Pharmacokinet,1984
2. ADMET in silico modelling: towards prediction paradise?;Waterbeemd;Nat Rev Drug Discov,2003
3. Gut wall metabolism. Application of pre-clinical models for the prediction of human drug absorption and first-pass elimination;Jones;AAPS J,2016
4. Is the role of the small intestine in first-pass metabolism overemphasized?;Lin;Pharmacol Rev,1999
5. Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations;Gertz;Curr Drug Metab,2008a
Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Use of Human Intestinal and Hepatic Tissue Fractions and Microbiome as Models in Assessment of Drug Metabolism and its Impact on Oral Bioavailability;Oral Bioavailability and Drug Delivery;2023-10-10
2. Effects of aqueous extract from Baiyedancong-Oolong tea on cytochrome P450 enzymes activities, P-gp and OATs transport abilities and transcription levels in mice;Frontiers in Nutrition;2023-05-09
3. The Interplay Between Drug Release and Intestinal Gut‐Wall Metabolism;Oral Drug Delivery for Modified Release Formulations;2022-04-08
4. Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics;Drug Metabolism and Disposition;2021-09-21
5. Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation;European Journal of Drug Metabolism and Pharmacokinetics;2020-12-19
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3