Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

Author:

Metushi Imir G.1,Sanders Corron2,Lee William M.2,Uetrecht Jack13,

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Medicine; University of Toronto; Toronto Ontario Canada

2. Division of Digestive and Liver Disease, Department of Internal Medicine; UT Southwestern Medical Center; Dallas TX

3. Department of Pharmaceutical Sciences, Faculty of Pharmacy; University of Toronto; Toronto Ontario Canada

Publisher

Wiley

Subject

Hepatology

Reference26 articles.

1. Severe isoniazid-associated liver injuries among persons being treated for latent tuberculosis infection-United States, 2004-2008;Center for Disease Control and Prevention;MMWR,2010

2. Isoniazid hepatitis;Maddrey;Ann Intern Med,1973

3. A fresh look at the mechanism of isoniazid-induced hepatotoxicity;Metushi;Clin Pharmacol Ther,2011

4. Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis;Mitchell;Ann Intern Med,1976

5. Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat;Nelson;Science,1976

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