Characterization of <scp> <i>RNF43</i> </scp> frameshift mutations that drive <scp>Wnt</scp> ligand‐ and <scp>R</scp> ‐spondin‐dependent colon cancer-Reference-Cited by-同舟云学术

Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R ‐spondin‐dependent colon cancer

Published:2022-03-04 Issue:1 Volume:257 Page:39-52
ISSN:0022-3417
Container-title:The Journal of Pathology
language:en
Short-container-title:The Journal of Pathology

Author:

Yamamoto Daisuke¹²³,Oshima Hiroko¹⁴^ORCID,Wang Dong¹⁴^ORCID,Takeda Haruna⁵^ORCID,Kita Kenji⁶,Lei Xuelian¹,Nakayama Mizuho¹⁴^ORCID,Murakami Kazuhiro⁷^ORCID,Ohama Takashi⁸,Takemura Hirofumi²,Toyota Mutsumi⁹,Suzuki Hiromu⁹^ORCID,Inaki Noriyuki¹⁰,Oshima Masanobu¹⁴^ORCID

Affiliation:

1. Division of Genetics, Cancer Research Institute Kanazawa University Kanazawa Japan

2. Department of Thoracic, Cardiovascular and General Surgery Kanazawa University Kanazawa Japan

3. Department of Gastroenterological Surgery Ishikawa Prefectural Central Hospital Kanazawa Japan

4. WPI Nano‐Life Science Institute (Nano‐LSI) Kanazawa University Kanazawa Japan

5. Laboratory of Molecular Genetics, National Cancer Center Research Institute Tokyo Japan

6. Central Research Resource Branch, Cancer Research Institute Kanazawa University Kanazawa Japan

7. Division of Stem Cell Biology, Cancer Research Institute Kanazawa University Kanazawa Japan

8. Laboratory of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan

9. Department of Molecular Biology Sapporo Medical University School of Medicine Sapporo Japan

10. Department of Gastrointestinal Surgery Kanazawa University Kanazawa Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.5868

Reference40 articles.

1. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

2. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

3. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

4. Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

5. RNF43 is frequently mutated in colorectal and endometrial cancers

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