Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

Author:

van der Ende Emma L.1,Meeter Lieke H.1,Stingl Christoph2,van Rooij Jeroen G. J.13,Stoop Marcel P.2,Nijholt Diana A. T.2,Sanchez-Valle Raquel4,Graff Caroline56,Öijerstedt Linn56,Grossman Murray7,McMillan Corey7,Pijnenburg Yolande A. L.8,Laforce Robert9,Binetti Giuliano1011,Benussi Luisa10,Ghidoni Roberta10,Luider Theo M.2,Seelaar Harro1,van Swieten John C.1

Affiliation:

1. Department of Neurology; Erasmus Medical Center; PO Box 2040 3015 GD Rotterdam The Netherlands

2. Laboratory of Neuro-oncology; Clinical and Cancer Proteomics; Department of Neurology; Erasmus Medical Center; PO Box 2040 3000 CA Rotterdam The Netherlands

3. Department of Internal Medicine; Erasmus Medical Center; PO Box 2040 3015 GD Rotterdam The Netherlands

4. Alzheimer's Disease and Other Cognitive Disorders Unit; Department of Neurology; Hospital Clínic; Institut d'Investigació Biomèdica August Pi i Sunyer; Villarroel, 170 08036 Barcelona Spain

5. Division of Neurogeriatrics; Department NVS; Karolinska Institutet; Center for Alzheimer Research; Visionsgatan 4 171 64 Solna Stockholm Sweden

6. Unit for Hereditary Dementias; Theme Aging; Karolinska University Hospital-Solna; 171 64 Stockholm Sweden

7. Department of Neurology; Penn Frontotemporal Degeneration Center; University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania

8. Alzheimer Center and Department of Neurology; Neuroscience Campus Amsterdam; VU University Medical Center; PO Box 7057 1007 MB Amsterdam The Netherlands

9. Clinique Interdisciplinaire de Mémoire (CIME); CHU de Québec; Département des Sciences Neurologiques; Université Laval; Québec Québec Canada

10. Molecular Markers Laboratory; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli; via Pilastroni 4 Brescia 25125 Italy

11. MAC Memory Clinic; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli; via Pilastroni 4 Brescia 25125 Italy

Funder

Deltaplan Dementie

Bluefield Project to Cure Frontotemporal Dementia

Stichting Dioraphte

ZonMw

Instituto de Salud Carlos III

EU Joint Programme - Neurodegenerative Disease Research

Fundacio Marato de TV3

Swedish Alzheimer foundation

Regional Agreement on Medical Training and Clinical Research

Stockholms Läns Landsting

Karolinska Institutet

Strategic Research Program in Neuroscience at Karolinska Institutet

Medicinska Forskningsrådet

Hjärnfonden

Old Servants foundation

Gun och Bertil Stohnes Stiftelse

Schörling Foundation

Ministry of Health

Publisher

Wiley

Subject

Neurology (clinical),General Neuroscience

Reference44 articles.

1. Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations;Lashley;Neuropathol Appl Neurobiol,2015

2. Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review;Seelaar;J Neurol Neurosurg Psychiatry,2011

3. Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration;Ghidoni;Neurology,2008

4. Progranulin levels in plasma and cerebrospinal fluid in granulin mutation carriers;Meeter;Dement Geriatr Cogn Dis Extra,2016

5. Progranulin: normal function and role in neurodegeneration;Eriksen;J Neurochem,2008

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