The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6

Author:

Tengesdal Isak W.12ORCID,Kitzenberg David1,Li Suzhao1,Nyuydzefe Melanie S.3,Chen Wei3,Weiss Jonathan M.3,Zhang Jingya3,Waksal Samuel D.3,Zanin-Zhorov Alexandra3,Dinarello Charles A.12

Affiliation:

1. Dept. Medicine; University of Colorado Denver; Aurora CO USA

2. Department of Internal Medicine; Radboud University Medical Center; Nijmegen The Netherlands

3. Kadmon Corporation; LLC; New York NY USA

Funder

Interleukin Foundation for Medical Research

Foundation for the National Institutes of Health

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference37 articles.

1. IL-17 and Th17 Cells;Korn;Annu. Rev. Immunol.,2009

2. Mechanisms regulating skin immunity and inflammation;Pasparakis;Nat. Rev. Immunol.,2014

3. The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses;Lowes;Trends Immunol.,2013

4. Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis;Mudigonda;Dermatol. Online J.,2012

5. Pathogenesis and therapy of psoriasis;Lowes;Nature,2007

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