Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia

Author:

Al-Kzayer Lika'a Fasih Y.1,Sakashita Kazuo1,Al-Jadiry Mazin Faisal23,Al-Hadad Salma Abbas23,Ghali Hasanein Habeeb23,Uyen Le T.N.1,Liu Tingting1,Matsuda Kazuyuki4,Abdulkadhim Jaafar M.H.5,Al-Shujairi Tariq Abadi5,Matti Zead Ismael I.K.5,Sughayer Maher A.6,Rihani Rawad7,Madanat Faris F.7,Inoshita Toshi8,Kamata Minoru9,Koike Kenichi1

Affiliation:

1. Department of Pediatrics; Shinshu University School of Medicine; Matsumoto, Nagano Japan

2. Department of Pediatrics; College of Medicine; Baghdad University; Baghdad Medical City Baghdad Iraq

3. Department of Pediatric Oncology; Children's Welfare Teaching Hospital; Baghdad Medical City Baghdad Iraq

4. Department of Laboratory Medicine; Shinshu University Hospital; Matsumoto Nagano Japan

5. Department of Pediatric Oncology; Central Teaching Hospital for Children; Baghdad Iraq

6. Department of Pathology; King Hussein Cancer Center; Amman Jordan

7. Department of Pediatrics; King Hussein Cancer Center; Amman Jordan

8. Japan Iraq Medical Network; Tokyo Japan

9. Japan Chernobyl Foundation; Matsumoto; Nagano Japan

Funder

Japan Chernobyl Foundation (JCF)

NGO (non-governmental organization), Matsumoto, Nagano, Japan

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference32 articles.

1. Signaling interplay in Ras superfamily function;Mitin;Curr Biol,2005

2. RAS and leukemia: From basic mechanisms to gene-directed therapy;Beaupre;J Clin Oncol,1999

3. The molecular pathophysiology of myeloid leukaemias: Ras revisited;Byrne;Br J Haematol,1998

4. Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic Leukemia and its therapeutic targeting;Knight;Front Oncol,2014

5. Children's Oncology Group. Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: A report from the Children's Oncology Group;Shu;Cancer Epidemiol Biomarkers Prev,2004

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