Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies

Author:

Krohn Lynne12ORCID,Öztürk Tuğba Nur345,Vanderperre Benoît26,Ouled Amar Bencheikh Bouchra26,Ruskey Jennifer A.26,Laurent Sandra B.26,Spiegelman Dan26,Postuma Ronald B.26,Arnulf Isabelle7,Hu Michele T. M.89,Dauvilliers Yves10ORCID,Högl Birgit11,Stefani Ambra11,Monaca Christelle Charley12,Plazzi Giuseppe1314,Antelmi Elena1314,Ferini‐Strambi Luigi15,Heidbreder Anna16,Rudakou Uladzislau12,Cochen De Cock Valérie1718,Young Peter16,Wolf Pavlina19,Oliva Petra19,Zhang Xiaokui Kate19,Greenbaum Lior202122,Liong Christopher23,Gagnon Jean‐François2425,Desautels Alex2426,Hassin‐Baer Sharon222327,Montplaisir Jacques Y.2428,Dupré Nicolas2930,Rouleau Guy A.126,Fon Edward A.26,Trempe Jean‐François31,Lamoureux Guillaume3453233,Alcalay Roy N.2334,Gan‐Or Ziv126ORCID

Affiliation:

1. Department of Human GeneticsMcGill University Montreal Quebec Canada

2. Montreal Neurological Institute, McGill University Montreal Quebec Canada

3. Department of PhysicsConcordia University Montreal Quebec Canada

4. Centre for Research in Molecular Modeling (CERMM)Concordia University Montreal Quebec Canada

5. PROTEO, The Quebec Network for Research on Protein Function, Engineering and Applications Quebec Quebec Canada

6. Department of Neurology and NeurosurgeryMcGill University Montreal Quebec Canada

7. Sleep Disorders Unit, Pitié Salpêtrière Hospital, Institute of Brain and Spinal Cord and Sorbonne University Paris France

8. Oxford Parkinson's Disease CentreUniversity of Oxford Oxford United Kingdom

9. Nuffield Department of Clinical NeurosciencesUniversity of Oxford Oxford United Kingdom

10. National Reference Center for Narcolepsy, Sleep Unit, Department of NeurologyGui de Chauliac Hospital, University Hospital Center Montpellier, University of Montpellier, National Institute of Health and Medical Research U1061 Montpellier France

11. Sleep Disorders Clinic, Department of NeurologyMedical University of Innsbruck Innsbruck Austria

12. University of Lille Nord de France, Department of Clinical Neurophysiology and Sleep CenterUniversity Hospital Center Lille Lille France

13. Department of Biomedical and Neuromotor Sciences, Alma Mater StudiorumUniversity of Bologna Bologna Italy

14. Scientific Institute for Research and Health CareInstitute of Neurological Sciences of Bologna Bologna Italy

15. Department of Neurological SciencesVita‐Salute San Raffaele University Milan Italy

16. Institute of Sleep Medicine and Neuromuscular Disorders, University of Münster Münster Germany

17. Sleep and Neurology Unit, Beau Soleil Clinic Montpellier France

18. EuroMov, University of Montpellier Montpellier France

19. Biologics Structural and Functional Research, Biopharmaceutics Development, Genzyme Framingham MA

20. Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel Hashomer Israel

21. Joseph Sagol Neuroscience Center, Sheba Medical Center Tel Hashomer Israel

22. Sackler Faculty of MedicineTel Aviv University Tel Aviv Israel

23. Department of NeurologyCollege of Physicians and Surgeons, Columbia University Medical Center New York NY

24. Center for Advanced Research in Sleep MedicineSacred Heart Hospital of Montreal Montreal Quebec Canada

25. Department of PsychologyUniversity of Quebec at Montreal Montreal Quebec Canada

26. Department of NeurosciencesUniversity of Quebec at Montreal Montreal Quebec Canada

27. The Movement Disorders Institute, Department of Neurology, Sheba Medical Center Tel Hashomer Israel

28. Department of PsychiatryUniversity of Montreal Montreal Quebec Canada

29. Division of Neurosciences, University Hospital Center of QuebecLaval University Quebec City Quebec Canada

30. Department of Medicine, Faculty of MedicineLaval University Quebec City Quebec Canada

31. Department of Pharmacology and TherapeuticsMcGill University Montreal Quebec Canada

32. Department of ChemistryRutgers University ‐ Camden Camden, NJ USA

33. Center for Computational and Integrative Biology (CCIB) Camden NY USA

34. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Medical Center New York NY

Funder

Canadian Institutes of Health Research

Fonds de Recherche du Québec - Santé

Michael J. Fox Foundation for Parkinson's Research

National Institutes of Health

Natural Sciences and Engineering Research Council of Canada

Parkinson's Disease Foundation

National Institute of Neurological Disorders and Stroke

National Institute of Mental Health

National Institute on Drug Abuse

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Cancer Institute

Canada Foundation for Innovation

W. Garfield Weston Foundation

Brookdale Foundation Group

Canada First Research Excellence Fund

Canadian Glycomics Network

Michael J. Fox Foundation

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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